A novel 3d transition metal high entropy alloy (TM HEA), CrCuFeTiV, was fabricated by arc-melting under a vacuum condition. Its phase component, microstructure, and compressive properties in the as-cast and annealed conditions were carefullyinvestigated. The experimental results showed that the alloys in both conditions consist of one BCC phase (CrV/FeTi-richregions), one FCC phase (Cu-rich), and one hexagonal Laves phase (Cr2Ti). It is suggested that the CrV-rich BCC phasepreferentially separates as dendritic centers. Subsequently, the Cr2Ti Laves phase and the FeTi-rich BCC phase solidify as adendritic outer layer. Finally, the FCC Cu-rich phase is squashed into the remaining interdendritic regions. Besides, the yieldstrength, ultimate strength, and hardness of the as-cast CrCuFeTiV alloy are 1686 MPa, 2205 MPa, and 624 HV, while thosefor the annealed alloy are 1510 MPa, 2035 MPa, and 618 HV, respectively. The obtained values are the highest among thetabulated fve-principle equiatomic Cu-containing 3d TM HEAs. The promising strength-hardness synergy of CrCuFeTiValloy is likely originated from the majority constitution of the BCC phase and Cr2Ti Laves phase.