Fault caused by earthquake is harmful to buried pipelines. Long-distance transportation pipelines will inevitably cross the seismic fault zones. In this paper, a numerical simulation model of X80 pipeline under reverse faulting with a crossing angle of 60° was established. Damage evolution mechanism of buried steel pipeline was analyzed. Effects of internal pressure and diameter-thickness ratio on the stress, strain and displacement of pipeline were discussed. The results show that the buckling phenomenon is more severe in the hanging wall than that in the footwall for reverse fault. For non-pressure pipeline, local collapse occurs on the compression side. When the pipeline wall buckles, the axial stress is released, and highstress is mainly concentrated on the collapsed position. For pressure pipeline, the internal pressure aggravates the buckling degree. Then, wrinkles appear on the compression side. The results can provide a reference for anti-seismic construction, repair and maintenance of buried pipeline.