An Efficient Synthesis of Substituted Furans by Cupric Halide-Mediated Intramolecular Halocyclization of 2-(1-Alkynyl)-2-alken-1-ones
- Resource Type
- Article
- Authors
- Weijun Fu; Feng-juan Xu; Wen-bo Guo; Mei Zhu; Chen Xu
- Source
- Bulletin of the Korean Chemical Society, 34(3), pp.887-891 Mar, 2013
- Subject
- 화학
- Language
- English
- ISSN
- 1229-5949
0253-2964
An efficient synthesis of 3-halofurans by the intramolecular cyclization of 2-(1-alkynyl)-2-alken-1-ones with cupric halide has been developed. A broad range of 3-chloro- and 3-bromofuran derivatives could be obtained in the present method in moderate to good yields. The 3-halofuran derivatives are potential synthetic intermediates for amplification of molecular complexity.