This paper studies the influence of parameters of a novel SMA helical spring energy dissipation brace on the seismic resistance of a frame structure. The force-displacement relationship of the SMA springs is established mathematically based on a multilinear constitutive model of the SMA material. Four SMA helical springs are fabricated, and the forcedisplacement relationship curves of the SMA springs are obtained via tension tests. A numerical dynamic model of a twofloor frame with spring energy dissipation braces is constructed and evaluated via vibration table tests. Then, two spring parameters, namely, the ratio of the helical spring diameter to the wire diameter and the pre-stretch length, are selected to investigate their influences on the seismic responses of the frame structure. The simulation results demonstrate that the optimal ratio of the helical spring diameter to the wire diameter can be found to minimize the absolute acceleration and the relative displacement of the frame structure. Meanwhile, if the pre-stretch length is assigned a suitable value, excellent vibration reduction performance can be realized. Compared with the frame structure without braces, the frames with spring braces exhibit highly satisfactory seismic resistance performance under various earthquake waves. However, it is necessary to select an SMA spring with optimal parameters for realizing optimal vibration reduction performance.