This paper is concerned with the adaptive synchronization of multi-agent systems via variable impulsive control method. Based on the theory of impulsive diferential equations, adaptive control technique, Lyapunov stability theory and comparison system method, some novel adaptive synchronization conditions with impulsive time window are given to realize the synchronization of multi-agent nonlinear systems with uncertain parameters. Diferent from the existing investigations of impulsive synchronization of multi-agent systems, the proposed impulsive control protocol with impulsive time window is more efective in practical systems. Finally, two simulation results demonstrate the validity of the theoretical results.