Nanodendritic Pt-based bimetallic alloys are one promising catalyst with three-dimensional (3D) networks structure composed of integrating branches for electrochemical catalytic reaction. We successfully synthesized dendrites Pt6Ir4 alloy with small size of 20 nm in oleylamine. The dendritic Pt6Ir4 alloy are characterized by high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The electrochemical tests suggest that the as-prepared dendritic Pt6Ir4 alloy exhibits greatly enhanced ethylene glycol oxidation reaction (EGOR) activity than commercial Pt/C with high EGOR mass activity, anti-poisoning and stability.