COVID-19 pandemic has unprecedented impact on the lives of urban residents in global cities. Due to the changing lifestyle facing the pandemic, global cities have experienced the structural shift in urban form. This paper aims to study the changing patterns of commuting (resulted from increasing work from home options), population (re)distribution, demand in office space at urban cores among the four global cities facing the COVID-19 pandemic. The four global cities included in this study are New York, London, Tokyo, and Los Angeles. Through meta-analysis among these four global cities, this paper compares the pandemic experience shapes the evolution of structural shifts in urban form. For all four cast study cities, the share of WfH (Work from Home) among workers has significantly increased during the pandemic and this pattern is expected to last in post-pandemic era. Population (re)distribution pattern differs slightly. In the global cities like New York, London, and Tokyo, intra-metro residential relocation was the main type of population redistribution. However, in Los Angeles, the inter-metro migration (mainly out-migration) to nearby metros with rapidly growing economy and more affordable housing options was the dominant type of population (re)distribution in pandemic. With the high WfH pattern in post-pandemic era, the observed population (re)distribution pattern is expected continue. Accordingly, demand for office space at urban core declines with higher vacancy rate and lower rental prices compared to that during the pre-pandemic period.