Due to the disadvantages of traditional solid-phase and liquid-phase methods for preparation of mixedmetal oxide ceramic pigments, it is indispensable to develop a green, clean, low-cost and continuouspreparation technology. In this study, the low-cost and high-performance cobalt ferrite ceramic pigmentswere facilely prepared based on natural mixed-dimensional palygorskite clay by a continuousmechanochemical method using twin-screw extrusion. The incorporation of the mixed-dimensionalpalygorskite clay effectively improved the agglomeration of pigment nanoparticles and decreased theproduction cost. The hybrid pigments presented the optimal color properties (L* = 17.16, a* = 1.07, b* =3.58 and C* = 3.74) when the cobalt ferrite content, calcination temperature and time were 60 wt%,1100 C and 90 min, respectively. Furthermore, the as-prepared hybrid pigments exhibited excellentchemical and thermal stability and biocompatibility, the mass tone and hiding power of the hybrid pigmentswere superior to the commercial cobalt black pigments, thus the obtained hybrid pigments couldbe served as an eco-friendly underglaze pigment for coloring of ceramic embryo body with good colorsaturation. Beyond all doubt, this study will provide a promising strategy for continuous cleaner preparationof low-cost cobalt ferrite ceramic pigments.