Developing highly-efficient and low-cost electrocatalysts act as pressing impacts on the flourishing ofhydrogen energy, including electrochemical water splitting is a kind of prevailing energy conversiontechnology. However, it is hampered by the high activation barrier of oxygen evolution reaction (OER). Herein, a hybrid electrocatalyst with trifunctional and 3D core–shell structure is designed by hydrothermalprocess in order to achieve outstanding OER, hydrogen evolution reaction (HER) and urea oxidationreaction (UOR) properties. NiSe@MoS2/NF catalyst is composed of the heterogeneous interface formed byNiSe nanowire arrays which supported by nickel foam and MoS2 nanosheets. The synergistic effect andstrong electronic interaction between the interface display the dominant impact of OER, HER and UOR. Especially in basic electrolyte, the potential is as low as 310 mV at 100 mA cm2, even Tafel slope is70.8 mV dec-1, representing the predominant OER property. The HER and UOR also demonstrate enormousprospect with 210, 233 mV at 100 mA cm2. When NiSe@MoS2/NF||NiSe@MoS2/NF catalyst asanode and cathode, only requires potential of 1.48 V at 10 mA cm2 for overall water splitting test. The work offers a plain, high-efficiency and inexpensive method to evolve the progressive trifunctionalelectrocatalysts for other energy-related applications.