Clinical findings and brain MRI findings of 5 cases with sepsis-associated encephalopathy / 敗血症関連脳症5例の臨床症状と脳MRI所見
- Resource Type
- Journal Article
- Authors
- Ichiro Yabe; Kaede Ishikawa; Kazuki Yamada; Shigehisa Ura; Taichi Nomura; Yuki Oshima; 大嶌 祐貴; 山田 一貴; 浦 茂久; 矢部 一郎; 石川 楓; 野村 太一
- Source
- Journal of Japan Society of Neurological Emergencies & Critical Care. 2022, 34(2):7
- Subject
- Sepsis-associated encephalopathy (SAE)
blood-brain barrier
cerebral infarction
vasogenic edema
敗血症関連脳症
脳梗塞
血液脳関門
血管性浮腫
- Language
- Japanese
- ISSN
- 2433-0485
2433-1600
Results: Age at symptom onset was high (61.6±12.9 years), with three patients having a history of hypertension. The Sequential Organ Failure Assessment score was high (11.6±4.82). Conscious disturbance appeared as a neurological complication in the early stages. The cause of sepsis was gastrointestinal infection in four patients. All five patients recovered from sepsis; however, four patients showed residual symptoms. We found slightly elevated protein levels in the cerebrospinal fluid. Brain MRI revealed multiple cerebral infarctions due to endothelial disturbance and vasogenic edema associated with disruption of the blood brain barrier.