간장장해에서 Theophylline의 체내동태
Pharmacokinetics of Theophylline in Rabbits with Hepatic Failure
- Resource Type
- Article
Text
- Authors
- 문흥섭; 이종기; 최준식; Moon, Hong-Sub; Lee, Chong-Ki; Choi, Jun-Shik
- Source
- 한국임상약학회지, 05/30/1992, Vol. 2, Issue 1, p. 23-28
- Subject
- Language
- 한국어(KOR)
- ISSN
- 1226-6051
This study was attempted to investigate the pharmacokinetics of theophylline(4mg/kg) in the rabbits of carbon tetrachloride induced hepatic Cailure, The plasma concentration and relative bioavailability of theophylline were increased significantly in hepatic railure rabbits compared with those of normal rabbits. There was significant relationship between SGOT value and bioavailability parameters of theophylline. From the results of this experiments, dosage regimen of theophylline is considered to be adjusted in dose size and dosing interval using SGOT values.