One Health is a concept that means the health of people, animals, and the environment are connected as one. The concept of One-health, which reflects recent topics such as climate crisis, ESG, and value consumption, is consistent with the educational philosophy of Christian universities and is highly related to the social welfare major. This study introduced the concept of One Health and explored the intersection of the Bible, Christian theology, and ethics, and proposed Christian social welfare education and practice plans. First, integrating One Health concepts into Christian social work education can provide a comprehensive and holistic approach to understanding the interconnections between human health, animal health, and the environment within the context of God's creation and stewardship framework. Second, integrating One Health principles into Christian social work practice programs can improve the capacity of social workers to solve complex health problems. Third, Christian social work can apply an ethical framework to One Health issues to promote the common good and advocate for social work practices and policies that are consistent with Christian values of justice, compassion, and responsible stewardship.