The traditional ESB brings great complexity to the enterprise information construction and digital transformation due to its centralized design, which is difficult to meet the flexible service iteration and demand delivery. In this paper, an integrated service bus model based on micro-service (ISB-MS) is proposed. The service management and monitoring routing are realized through the micro-service architecture, and the unified management of enterprise information system interfaces is realized through two data interaction methods. The model uses Kafka as the message communication middleware, provides asynchronous message interaction interfaces, and increases the reliable transmission mechanism of identity authentication and data backup. The throughput of the ISB-MS model is maintained at about 40000Byte. At the same time, it can reduce the time overhead of data interaction, shorten the response time, and reduce the error rate of data interaction. The model has been running stably in a hospital information construction for three months, achieving the goal of high reliability, high efficiency and high scalability of data interaction.