This paper calculates the Air Quality Index (AQI) in Xuzhou from 2018 to 2020 and analyzes its annual and monthly changes in air quality to determine the month of severe pollution. Through AQI calculation and interpolation analysis of different locations in Xuzhou, the air quality conditions in different regions are determined. Through the HYSPLIT backward trajectory model, cluster analysis of the air masses in December 2020 is carried out. Combined with the PM2.5 concentration data released every hour by the Xuzhou State Control Station, PSCF and CWT methods are used to determine potential sources of PM2.5 pollution in different regions. This paper also uses the hourly PM2.5 data in Xuzhou area obtained from the retrieval of the Himawari-8/AHI AOD through the IGTWR model for the traceability analysis of pollutants. The results show that there are large potential pollution sources in Henan, northern Anhui, northern Hubei and other places. At the same time, pollutant emissions in parts of northern Jiangsu, southern Shanxi and Shandong province also contribute to PM2.5 in Xuzhou. This paper also traced the source of the PM2.5 heavy pollution days in Xuzhou in December 2020 and determined the location of the specific pollution source based on the actual situation.