Silicon photomultiplier (SiPM) is one of the best choices for Positron Emission Computed Tomography (PET) detectors due to its excellent properties. In order to achieve high fill factor of SiPM tile for PET detector, we have developed a small “dead zones” packaging technology based on lithography, SU-8 photoresist and conductive silver paste rather than Au wire bonding. It was simple, cost-effective to form a small “dead” zone as small as 60 µm of packaging SiPMs for mass production, the ratio of chip area to packaged device area is as high as 0.9037. The preliminary yield reached 49.8%.