In the past decade, natural disasters such as hurri-canes have challenged the operation and control of U.S. power grid. It is crucial to develop proactive strategies to assist grid operators for better emergency response and minimized electricity service interruptions; the better the grid may be preserved, the faster the grid can be restored. In this paper, we propose a proactive posturing of power system elements, and formulate a Security-Constrained Optimal Power Flow (SCOPF) informed by cross-domain hurricane modeling as well as its potential impacts on grid elements. Simulation results based on real-world power grid and historical hurricane event have verified the applicability of the proposed optimization formulation, which shows potential to enable grid operators and planners with interactive cross-domain data analytics for mitigating hurricane impacts.