Evolutionary strategic choice algorithm of the professional cultural guiding in local newly-built college based on multi-view data mining is designed and implemented in the paper. Memory database abandons the traditional way of disk data management, redesigns the architecture based on all data in memory, and makes corresponding improvements in data cache, fast algorithm and parallel operation, so the data processing speed is much faster than that of traditional database. The data information instructions can be described by using the algorithm flow chart. The algorithm expression in the data structure is compiled through symbols or words and the variable may be reused many times in the system of equations. With this regard, this paper then applies the model into the strategic choice algorithm of the professional cultural guiding in local newly-built college. The framework is simulated through the consideration of the parameters and the performance is validated.