In this work, we propose a proportional-integral (PI) control strategy for strict-feedback systems subject to full-state constraints as well as input saturations, where input saturation is dealt with by a smooth approximatelion function, while the asymmetric full-state constraints are addressed through a nonlinear state-dependent transformation. It is shown that the proposed control strategy circumvents the feasibility conditions and bears the simple structure of PI control, which makes resultant control strategy robust, adaptive and fault- tolerant. Simulation validates the feasibility and performance of the proposed control method.