In this paper, we present a low-cost, robust and high-sensitivity microwave-microfluidic sensor system based on a 11 × 11 arrays of symmetric composite SRR (SCSRR). The proposed microwave passive device, which operates at around 11 GHz-22GHz and is excited by a pair of patch antennas, is designed to identify different liquid samples with high permittivity, such as water-ethanol mixtures of different concentrations. Microfluidic channel is integrated into the substrate interior which improves device integration greatly. The simulated results show that the resonant frequency shift △f of these two resonance peaks at 13.29 GHz and 20.85 GHz is around 2.5 GHz and 6.5 GHz as the liquid samples permittivity changes from 9 to 80. The proposed metamaterial-inspired sensor has higher sensitivity and larger frequency shift △f on liquid samples compared with the conventional sensor reported in other literatures. As a passive device, this metamaterial-microfluidic sensor offers a potential lab-on-chip solution for liquids with high permittivity.