The spread of the COVID-19 epidemic has triggered realistic thinking about the renewal of traditional interior spaces. How to enhance the ability of future residents to cope with major emergencies through spatial resilience is an important concern for interior smart space design in the post-epidemic era. This paper discusses how to make effective use of interior layout, divide interior space more rationally and create a green and healthy interior space design, with three aspects of spatial emergency protection, spatial resilience and spatial affinity, and gives specific consideration to the transformation of interior smart space.