The scaling of the water injection pipeline seriously affects the water injection efficiency. Current research is generally limited to the selection of suitable cleaning technology, and there are too few studies on the cleaning effect. In this paper, after analyzing the scaling mechanism and scaling evaluation model of the water injection pipeline, a simulation system is designed based on the GUI interface of the MATLAB platform to simulate the cleaning effect. The original data of the oilfield water injection pipeline can be imported into the simulation system, the cleaning technology can be selected and its cleaning effect can be simulated, and the evaluation method of the cleaning effect is given in the paper. The cleaning result can be obtained by comparing the data before and after cleaning. Based on the original data of an oil field, this paper carried out a simulation of the cleaning effect of chemical cleaning, and reached a conclusion that the cleaning effect was obvious. Application examples show that the water injection trunk lines that need to be cleaned in the two water injection stations have been obviously improved after cleaning, but the cleaning effect of different water injection stations is different, so the cleaning technology can be adjusted in time according to the simulation, which is more conducive to the choice of pipeline cleaning technology, thereby improving water injection efficiency.