Aiming at the problem of anti-missile threat assessment, an anti-missile threat assessment method based on improved grey correlation analysis is proposed. This method determines the weight of the evaluation index through the combination empowerment method, effectively solves the problem that the single subjective empowerment method is too strong, and the single objective empowerment method relies too much on the shortcomings of objective and accurate information, making the weight of the evaluation index more scientific and reasonable. This ensures that the evaluation results are more scientific and reasonable. Among them, the subjective weight is determined based on the structure entropy method, and the objective weight is determined based on the deviation maximization method. The experimental results show that the anti-missile threat assessment method based on the improved grey correlation analysis method is scientific and effective.