This paper mainly proposes an incentive mechanism of mobile health service supply chain under doctors' efforts level information asymmetry. We consider a two-stage supply chain consisting of a mobile health service platform and a contracted doctor. In order to coordinate the supply chain, we design an incentive mechanism by combining principal-agent theory and two-part tariff contract. The numerical examples show some interesting findings:(1) Through optimizing the signing fee and commission rate, the incentive mechanism can motivate the doctor to provide services at an optimal efforts level, so as to eliminate the negative impact of information asymmetry on the supply chain. (2) In the proposed model with the doctors' efforts level information asymmetry, the mobile health service platform can increase its profit by increasing the penalty fee, service sales price, signing fee and commission rate.