MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability
- Resource Type
- Conference
- Authors
- Cook, Colin; Komatsu, Hirotake; Salgado, Mayra; Mullen, Yoko; Kandeel, Fouad; Tai, Yu-Chong
- Source
- 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII), 2019 20th International Conference on. :2221-2224 Jun, 2019
- Subject
- Bioengineering
Components, Circuits, Devices and Systems
Fields, Waves and Electromagnetics
Photonics and Electrooptics
Power, Energy and Industry Applications
Robotics and Control Systems
Blades
Silicon
Micromechanical devices
Insulin
Etching
Rats
Diabetes
islets
oxygen
cutter
sectioning
silicon
hypoxia
MEMS
viability
diffusion
- Language
- ISSN
- 2167-0021
This paper reports on the first MEMS silicon cutters designed to rapidly section donor pancreatic islets below oxygen diffusion-limited dimensions to improve viability of grafts during the critical period of re-implantation and revascularization by the host. The monolithic silicon chips feature an array of spaced nano-sharp (r < 100 nm) blades that cleanly section islet tissue. This work represents the first time that sectioning of pancreatic islets has been proposed and validated as a means to overcome the well-known problems of hypoxia and core-necrosis that is encountered in current islet transplantation procedures.