In order to solve the problem of value appreciation and evaluation of pharmaceutical manufacturing enterprises, we propose an automatic decision-making value system model. Firstly, by applying blockchain and smart contracts, we design general model and basic technology architecture of automatic decision-making value system. Then, by analyzing the characteristics of the value chain of the pharmaceutical manufacturing industry, we further construct an automatic decision-making value system model applied in the pharmaceutical manufacturing industry, and propose an index system for enterprise value evaluation based on four dimensions of integration, optimization, control and value-added satisfaction. Finally, the case explains the application of the value system that can be used in conjunction with the alliance chain, the private chain, the public chain, and the process of enterprise value assessment. The automatic decision value system model can help optimize the enterprise value chain and assess the true value of the enterprise from four aspects: integration, optimization, control, and value-added satisfaction.