Ultrasound and Microbubble-Mediated Targeted Delivery of Drug Loaded Nanoparticles to Porcine Liver
- Resource Type
- Conference
- Authors
- Di Ianni, Tommaso; Bachawal, Sunitha; Wang, Huaijun; Bose, Rajendran J. C.; Sukumar, Uday K.; Telichko, Arsenii; Herickhoff, Carl; Baker, Sam; Felt, Stephen A.; Paulmurugan, Ramasamy; Dahl, Jeremy
- Source
- 2018 IEEE International Ultrasonics Symposium (IUS) Ultrasonics Symposium (IUS), 2018 IEEE International. :1-9 Oct, 2018
- Subject
- Aerospace
Bioengineering
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Fields, Waves and Electromagnetics
Signal Processing and Analysis
Liver
Animals
Ultrasonic imaging
Cancer
Drugs
Tumors
- Language
- ISSN
- 1948-5727
In this paper, we adapt and validate a platform for ultrasound (US)and microbubble (MB)-mediated delivery of drug-loaded poly lactic-co-glycolic acid nanoparticles (NPs)to liver cancer in a large animal model as a further step toward clinical translation. A single-probe ultrasound setup was used for image-guided NP delivery using clinically approved MBs. Acoustic parameters were optimized in a phantom study. Experiments were conducted in a healthy pig model to validate the platform and test the delivery efficacy in vivo. The US/MB treatment resulted in 1.9-fold increase in expression of exogenous anticancer microRNA with respect to an untreated liver region and 1884-fold increase relative to a control animal.