Three-Dimensional Radiopharmaceutical-Excited Fluorescence Imaging of Lymph Nodes
- Resource Type
- Conference
- Authors
- Guo, Hongbo; He, Xiaowei; Liu, Muhan; Zhang, Zeyu; Hu, Zhenhua; Tian, Jie
- Source
- 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2017 IEEE. :1-3 Oct, 2017
- Subject
- Bioengineering
Components, Circuits, Devices and Systems
Computing and Processing
Nuclear Engineering
Photonics and Electrooptics
Lymph nodes
Nanobioscience
Three-dimensional displays
Molecular imaging
Mice
Image reconstruction
radiopharmaceutical-excited fluorescence imaging
lymph nodes imaging
3D reconstruction
- Language
- ISSN
- 2577-0829
Optical imaging techniques have been developed for localizing lymph nodes before surgical resection due to the non-invasion and high sensitivity. However, its attendant penetrability limitations and auto-fluorescence effect have greatly limited the spatial resolution and imaging precision. In this study, a novel technique radiopharmaceutical-excited fluorescence imaging (REFI) was adopted to image lymph nodes, which use gamma-ray and Cerenkov radiation from radioisotopes to excite lanthanide europium oxide (EO) nanophosphors and boost the light intensity. An effective adaptive-steepest-descent-projection onto convex sets (ASD-POCS) reconstruction algorithm and the anatomic structure information were used to three-dimensionally image lymph nodes in mice models. The results indicate that REFI can greatly boost the light intensity and accuracy of threedimensional imaging of lymph node with location deviation less than 1.03 mm.