Identification of cancer drug sensitivity biomarkers
- Resource Type
- Conference
- Authors
- Ullah, Ehsan; Mall, Raghvendra; Bensmail, Halima; Rawi, Reda; Shama, Saila; Muftah, Nooral Al; Thmpson, Ian Richard
- Source
- 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Bioinformatics and Biomedicine (BIBM), 2017 IEEE International Conference on. :2322-2324 Nov, 2017
- Subject
- Bioengineering
Computing and Processing
Drugs
Bioinformatics
Genomics
Cancer
Sensitivity
Gene expression
cancer
drug sensitivity
biomarkers
genomics
association analysis
statistical analysis
- Language
Anti-cancer therapies have different responses to different patients. There is a need to identify biomarkers for effectiveness of drugs beside the biomarkers for the diseases like cancer to advance the field personalized medicine. We have used a panel of cancer cell lines from Genomics of Drug Sensitivity in Cancer (GDSC) to capture the sensitivity of drugs. By combining the genetic information such as mutations, copy number variations and gene expression levels from Catalogue of Somatic Mutations in Cancer (COSMIC) and The Cancer Genome ATLAS (TCGA) for the afore mentioned cell lines, we are able to identify genomic features associated with the sensitivity of the drugs.