Fatty liver disease(FLD) is one of the most frequently encountered liver disease and could progress to steatohepatitis, cirrhosis and liver failure. The staffs in university is a kind of special occupational group whose work is primarily mental work. We analysed the physical examination data of 500 university staffs in Changchun city in 2010, the incidence of fatty liver disease among university staffs was 36.60% Sex and age were two important factors that affect the incidence of FLD. FLD frequently coexists with obesity, hyperlipidemia, hyperglycemia, hypertension and elevated Alanine Transaminase (ALT). We suggested that main control strateies for university staffs were Changing lifestyle, stopping drinking, losing weight, remaining healthy mentality, periodical medical examination and early treatment for FLD and underlying conditions of FLD.