From the building practice of Hindu Kush-Himalayan Region (HKH region) Geographic Information Sharing Network China Node, this paper preliminary discusses spatial data infrastructure for regional cooperative research. Focus on the research of its framework, key technologies, core function etc. Select related data resources integrated on Data Sharing Network of Earth System Science for deep processing and translation, customize and develop sharing platform based on open source GeoNetwork to publish the data and related metadata. HKH Region Geographic Information Sharing Network China Node provides realizable support for the research of regional environment, resources and sustainable development.