Aimed at the large amount of test cases in handset’s software testing and tremendous manual work, this paper adopted orthogonal experiment to generate test cases after comparing three algorithms which are genetic algorithm, formal specification and orthogonal experiment. By constructing the experiment and analysing their difficulties, maneuverability, coverage rate and rigour, etc, it is concluded that orthogonal method could not only generate test cases more easily and simplify them more efficiently but also make the reduced cases representative. Finally, take calendar of a simulator for exapmle, we use orthogonal experiment to extract its factors and levels, and generate the cases by Test Case Generation Tool which is prorammed in Visual Studio. Through the analysis of the paired-coverage rate of these cases, it is concluded that orthogonal experiment is suitable for phone’s test case generation.