This study tested whether or not an integrated stress management intervention program can reduce job burnout and increase work well-being among Chinese health care employees. To this end, a one-group pretest-posttest design was adopted, and paired t-tests were used to verify the effects of the intervention training course program. 200 health care workers were recruited from Chinese public hospitals to participate in a three-day training course held in 4 separate classes, with an average of 50 persons in each class. A total of 162 matched participants (33 males, 129 females) completed the pretest and posttest surveys. The results obtained from paired t-tests consistently demonstrated reductions after training in job burnout and its three dimensions, including emotional exhaustion, depersonalization and reduced personal accomplishment, and improvements in work well-being, positive emotions, and work-family balance. Implications of these findings for research and practice are discussed.