Synchronous rectification offers an effective solution to improve efficiency of low-output-voltage flyback converters. Conventional synchronous flyback topologies using discrete synchronous rectifier face challenges in precise timing control on the secondary side. In this paper, MHz-frequency operation of a flyback DC-DC converter using a new monolithic self-synchronized rectifier (SSR) is investigated and demonstrated. The SSR IC, acting solely on its own drain-source voltage instead of external control signals, considerably simplifies converter design, improves system efficiency, and enables MHz operating frequency. Analysis, modeling, and experimental results are presented.