Amyloid-ss Dynamics Correlate with Neurological Status in the Injured Human Brain
- Resource Type
- Conference
- Authors
- Brody, David L.; Esparza, Thomas J.; Magnoni, Sandra; Stocchetti, Nino; Schwetye, Kate E.; Zipfel, Greg J.; Spinner, Michael; Holtzman, David M.
- Source
- 2009 3rd International Conference on Bioinformatics and Biomedical Engineering Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on. :1-3 Jun, 2009
- Subject
- Bioengineering
Communication, Networking and Broadcast Technologies
Computing and Processing
Humans
Extracellular
Alzheimer's disease
Nervous system
Brain injuries
Peptides
Fluid dynamics
Amino acids
Anesthesia
Patient monitoring
- Language
- ISSN
- 2151-7614
2151-7622
The amyloid-beta peptide (Abeta) plays a central pathophysiological role in Alzheimer's disease, but virtually nothing is known about the concentration and dynamics of this secreted peptide in the extracellular space of the human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were undergoing invasive intracranial monitoring after acute brain injury. We found a strong positive correlation between changes in brain ISF Abeta levels and neurological status, and correlations with other cerebral physiological and metabolic abnormalities reflecting depressed neuronal function. Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Abeta concentration.