Clustering of individuals given SNPs similarity based on normalized mutual information: F7 SNPs in the GAIT sample
- Resource Type
- Conference
- Authors
- Perera, Alexandre; Buil, Alfonso; Di Bernardo, Maria Chiara; Sabater-Lleal, Maria; Pattini, Linda; Souto, Juan Carlos; Fontcuberta, Jordi; Vallverdu, Montserrat; Soria, Jose Manuel; Caminal, Pere
- Source
- 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE. :123-126 Aug, 2007
- Subject
- Bioengineering
Mutual information
Genetics
Biomedical measurements
Genomics
Bioinformatics
Proteins
Costs
Humans
Sequences
Cardiology
- Language
- ISSN
- 1094-687X
1558-4615
This paper proposes the clustering of individuals given their genotype using a normalized Mutual Information dissimilarity distance. This method is applied to a Single Nucleotyde Polymorphism set belonging to F7 gene, uncovering the intrinsic genetic variability on one Spanish population. This genetic variability corresponds to results published using a complete different approach in population genetics literature. Identified groups are shown to express significant differences in the level of FVII concentration.