When correcting the errors of the power metering automation system, the correction amplitude is quite different from the actual error state due to the non-uniform characteristics of the sampling. Therefore, the active secondary correction algorithm for the errors of the power metering automation system under nonuniform sampling is proposed. Combined with the influence of nonuniform sampling on the data information of the power metering automation system, the specific error is comprehensively analyzed. Based on the analysis results, the correction of the non-uniform error of the power metering automation system is realized based on the adaptive improvement of the double quadratic interpolation algorithm. The test results show that the design of correction algorithms can achieve precise correction of errors, and the correction effect for errors has high stability.