Aiming at the high coupling of the power information physical system, this paper uses the AC power flow model to model, and proposes a two-layer physical-information system cooperative attack model considering reactive power regulation. Firstly, based on the nonlinear state estimation model, a false data injection attack model which can avoid bad data detection is established. Then, based on the interaction behavior of attack and defense, a two-layer optimization model of physical-information cooperative attack considering reactive power regulation is constructed. The upper layer model optimizes the generated attack vector, and the lower layer model optimizes the scheduling behavior of the defender. Finally, the IEEE14-node system is taken as an example to simulate the established model, and the genetic algorithm and interior point method are used to solve the model. The simulation results show that the regulation of reactive power has a great influence on the attack on the power system, which provides a theoretical basis for the study of the defense methods of the subsequent attack on the power system.