To reduce the cost of global wiring and the failure rate of integrated circuits, an improved particle swarm optimization method is proposed for the global wiring optimization of integrated circuit clock networks. According to the global wiring process of the integrated circuit clock network, we construct a global wiring plane and a global wiring model under the Harman architecture. The particle swarm optimization algorithm is improved through particle mutation, initializing the particle population, and constructing a fitness function to calculate the particle fitness value. We continuously update the speed and position of particles until the termination conditions are met, output the optimal result, and complete the global routing optimization method for the integrated circuit clock network. The experimental results show that the optimized method in this paper significantly reduces wiring costs and the fault rate of integrated circuits.