A symmetric double-Y type microfluidic-based metamaterial terahertz sensor is investigated in this manuscript. By optimizing the dimensions, the sensor is designed to operate at 1.03THz. By employing the Fabry-Perot (FP) cavity channel, the interaction between the terahertz wave and the sample is enhanced, effectively mitigating the impact of water on the detection outcomes. The designed sensor produces an inductive-capacitive (LC) resonance with a quality factor of approximately 204, while demonstrating a maximum sensitivity of 246 GHz/RIU. Furthermore, the symmetric cell structure demonstrates excellent polarization and incident angle insensitivity within a 30-degree angle range, showing promising potential for biological detection. At the end, the concentration characterizations of glucose solution and aqueous ethanol solution were carried out using the designed sensor by using simulations.