In order to solve the problem of lack of effective detection means and insufficient detection automation for the API interfaces of the basic platform, the API interface detection scheme of the basic platform of the centralized control system is formulated. The API interface detection system based on the multi-agent model is further built, adopting a design architecture that separates test case management and execution, preparing test cases according to the application software development requirements, which can completely cover the API interfaces of the basic platform under test, and standardize the usage and performance of the API interfaces of the system under test. It has effectively promoted the construction of an open ecological model of “platform + application” of a new generation of centralized monitoring system for substations.