Socio-Cyber-Physical Systems are ubiquitous in today’s world. They are inherently complex systems built out of many large-scale systems that encompass different perspectives and numerous stakeholders. This leads to several challenges in managing their complexity and emergent behavior. In addition, these systems tend to include many adaptive and autonomous systems with different goals and different adaptations to environment changes or failures. The design, analysis, and testing of such systems is inherently challenging but is becoming critical due to their wide adoption. In this panel, we aim to discuss some of these challenges and potential solutions.