Digital signal amplifier circuit is also a typical amplifier circuit, which is commonly used in various electronic engineering designs. In the process of analog signal processing, there is a very direct relationship between sampling frequency and signal frequency. In this paper, an improved GA (Genetic Algorithm) based conversion method between analog signal and digital signal of single chip microcomputer is proposed. We use the improved GA of binary matrix coding method to obtain the appropriate analysis wavelet. The basic idea is to establish a cost function for the error between the signal and its approximation, and transform the above problem into an optimization cost function. The optimization process varies with the analysis wavelet. We use improved GA to solve this optimization problem, so as to obtain the best approximation of the signal. The research results show that compared with the traditional processing system, the designed system can effectively control the mean square error of filtering after effectively integrating GA with the integrated single chip microcomputer control signal processing system, which proves that the system can effectively process the control signal.