Throughout the ages, osteoarthritis has always been a chronic disease of huge concern because it brings great suffering to lots of people. According to the survey results of the Framingham Osteoarthritis study, the prevalence of knee osteoarthritis in the elderly has been on the rise, and the incidence of women is higher than that of men [1]. The disease rate increases as age increases, with respect to the age distribution of patients. Among those over 60 years of age in the United States, the prevalence of tibiofemoral radiographic knee osteoarthritis (RKOA) and symptomatic RKOA are as high as 37.4% and 12.1%, respectively, and the latter affects more than 10% of Americans [2]. In addition, recent statistics show that this disease is rapidly spreading to younger people, and it is imperative to find the cause of arthritis and prevent it.