The study uses machine learning to determine the accuracy of different algorithms for predicting MetS. Early prediction of MetS through routine health screening is an important goal for preventive medicine. The subjects in this study were employees aged 20 to 65 years old who signed a consent form for in-hospital health screening data were collected from 2015 to 2020. Total of 3538 individuals who underwent health screening were included in this study. Baseline characteristics of the 315 participants diagnosed with metabolic syndrome and 3222 participants without metabolic syndrome. This is a machine learning approach to identify metabolic syndrome using biochemical values and lifestyle habits. We found that the F1 score for detection of metabolic syndrome by neural network is the most accurate and higher compared to other models. Our study also identified some new indicators, including heart rhythm, RBC, WBC, Hb, and uric acid, as candidates for better detection of metabolic syndrome.