The destructive effect of sulfide on the insulation performance of transformer should not be ignored. Therefore, reducing the destructive effects of sulfide has become an important research topic. As a kind of cheap and non-toxic material with excellent chemical stability and wide sources, TiO 2 has good adsorption performance. In this paper, based on the molecular dynamics simulation method, the adsorption properties of different mass fractions of TiO 2 in mineral insulating oil to DBDS, n-hexetylmercaptan represented by large molecular sulfide and hydrogen sulfide represented by small molecular sulfide. The results show that the addition of TiO 2 can reduce the chance of forming hydrogen bond between sulfide molecules and insulating paper and copper windings, and inhibit the corrosion of sulfide molecules on transformer insulation system. This paper provides reference value for the study of preventive measures of sulfide.