In the medium and low voltage power grid, the serial power grid connection is a common operation mode of the power grid. The remote backup power automatic throw-in can effectively solve the power supply reliability of the serial power grid connection, but limited by communication, the remote backup power automatic throw-in is rarely used in the medium and low voltage power grid. This paper provides a principle and implementation of remote backup power automatic throw-in of substation with multiple-communication modes. By setting a wireless router in each remote backup power automatic throw-in device, The router realizes the point-to-point communication of the remote backup power automatic throw-in device by using the generic routing encapsulation(GRE) tap mode, thus realizing the information interaction function of the substation remote backup power automatic throw-in device with multiple-communication modes. The simulation model built in RTDS verifies that the proposed remote backup power automatic throw-in device with multiple communication modes is feasible. This method does not need to change the original software and hardware of remote backup power automatic throw-in device, avoids the problem that the existing technical scheme is easily limited by communication, makes the remote backup power automatic throw-in device more convenient, reliable and simple in structure, and greatly improves the possibility of application in medium and low voltage power grids.