Dermoscopy has been widely used in the clinical diagnosis of various skin lesions. However, how to observe the pigment structure in the epidermis, junction and dermal papillary layer more clearly and accurately still needs to be improved. The epidermal layer of the skin is similar to the mirror reflection, for which a portable dermatoscope with a field of view of 22 mm, a magnification of 10X, and a uniformity of about 85% is designed based on polarized imaging and uniform illumination, which can observe lesions and tissue morphology of deep skin tissues more precisely, thus improving diagnostic efficiency and accuracy.