The COVID-19 epidemic has largely restricted the traditional offline medical treatment model. In this study, we designed ECG monitoring smart clothing based on the Holter system after identifying and analyzing the needs of patients and doctors. This clothing is a wearable device that integrates monitoring and remote diagnosis, building a general network platform to realize remote data transfer sharing and online interactive auxiliary diagnosis. Wearable clothing that can monitor ECG in real time is designed and developed by intelligently integrating limb lead wires, conductive fiber fabrics, lead interfaces, and electrode signal storage receivers by using the human body sensing conduction principle of real-time ECG monitoring. Wearable real-time ECG monitoring clothing can help patients achieve fast virtual medical care and auxiliary diagnosis, and solve the design issues with electrode signal storage receivers.