Aim. Amiodarone, can be a life-saving medication however it can also cause amiodarone-induced thyroiditis (AIT). AIT is a complex and life-threatening side effect which can cause significant cardiac dysfunction and lead to cardiac failure. A small sub-group do not respond to medical therapy and their cardiovascular function continues to deteriorate. This select group is referred for a semi-elective total thyroidectomy. Without surgical removal of their thyroid gland these patients have a 30-50% mortality rate. Though surgery is known to be safer in euthyroid patients, prolongation of medical therapy can lead to worsening of heart function and higher surgical risk. This research aims to evaluate the safety of surgical management of AIT in those who have failed medical treatment. Method. A comparison was made between a group of surgically-treated AIT patients to a group of patients undergoing total thyroidectomies for alternate reasons. The patient demographics, ASA states, weight of the thyroid gland, surgical complications, anaesthetic complications and incidence of thyrotoxic crisis were assessed. Results. This research has shown that a total thyroidectomy is a relatively safe procedure to treat AIT that is not responding to medical therapy. Similar complication rates between the two groups were evident. Coinclusion. Total thyroidectomy is an equivocally safe procedure to perform in patients with AIT. Clinical Significance. Surgeons can consult their patients with realistic risks for their surgery. treating physicians can feel confident that surgery is a safe option for their patients with amiodarone-induced thyroiditis.