Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
- Resource Type
- article
- Authors
- Qiaozhen Cui; Chen Wang; Qichen Wang; Juanxiu Qin; Min Li; Baixing Ding; Zhen Shen
- Source
- Emerging Infectious Diseases, Vol 29, Iss 11, Pp 2398-2400 (2023)
- Subject
- Medicine
Infectious and parasitic diseases
RC109-216
- Language
- English
- ISSN
- 1080-6040
1080-6059
We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for blaSHV-12, leading to blaSHV-12 overexpression and ceftazidime/avibactam resistance. Genetic rearrangement contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.